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084f2db8c6 Close ScienceDirectSign inSign in using your ScienceDirect credentialsUsernamePasswordRemember meRegister nowForgotten username or password?Sign in via your institutionOpenAthens loginOther institution loginHelpJournalsBooksJournalsBooksSign inHelpcloseSign in using your ScienceDirect credentialsUsernamePasswordRemember meRegister nowForgotten username or password?Sign in via your institutionOpenAthens loginOther institution login . or its licensors or contributors. As a result they are currently the most widely used vector in clinical gene therapy protocols, with the majority of studies based on Ad serotype 5 . Crystallographic and cryoelectron microscopy techniques have been employed to identify the key amino acid residues within the hexon responsible for binding FX and. However, the safety and efficacy of Ad5 following intravascular administration are hampered by two major factors, these being the substantial propensity of the virus to transduce the liver, along with immune recognition of the virus , , and. Related book content No articles found. Cookies are required to use this site. Following sequential rounds of screening, three compounds, T5424837, T5550585 and T5660138 were identified that ablated FX-mediated Ad5 transduction with low micromolar potency. Kellye, Andrew H. ScienceDirect is a registered trademark of Elsevier B.V.RELX Group Recommended articles No articles found.
For more information, visit the cookies page.Copyright 2016 Elsevier B.V. Click the View full text link to bypass dynamically loaded article content. Focused, mini-libraries were generated with structurally related molecules and in vitro screening revealed novel hits with similar or improved efficacy. The candidate molecules possessed common structural features and formed part of the one pharmacophore model. We developed a high throughput screening (HTS) platform to identify small molecule inhibitors of FX-mediated Ad5 gene transfer. Citing articles (0) This article has not been cited. Pre-existing neutralising antibodies and the resident liver macrophages, Kupffer cells, sequester a large proportion of the viral load and contribute to the host inflammatory response . Such effects are determined by a range of complex interactions including those with neutralising antibodies, blood cells and factors, as well as binding to native cellular receptors (coxsackie adenovirus receptor (CAR), integrins). Download PDF Opens in a new window. Screen reader users, click the load entire article button to bypass dynamically loaded article content.